Friend of mine is ex-Army (with whom I climbed Whitney MR in 2006). He could not believe it when I said he would have great difficulty carrying a 100lb pack at high altitude.

No, we did not have that much on the MR, but the altitude effect humbled him. On a later trip, with proper acclimatization this time, he did go to 23,000ft on the Lhotse Face, so he really is a tough guy. Thin air is an equalizer. Harvey