I think the biggest concern would be to work on hydration. Long airplane flights tend to dehydrate people anyway.
The drier climate of the west also affects people. People tend to think if they are not sweating they don't need
a lot of water. Most of the water is lost through the lungs in the high and dry Sierra. After flying all day from
Ontario, drinking a lot of water and eating a good meal and camping at 5000-6000 feet the first night would
be enough of an adjustment. Two more nights at 10,000+ before going above 12,000 would also help.
Keeping your eye on your urine color is a good indication of your hydration levels.