As hikers prepare for their Mt. Whitney trips, we see questions regarding acclimatization to altitude. The following links are to scientific studies on that topic from civilian and military sources. Some of it is very technical, while others are a little more readable. What are they saying in general terms?
In brief, science shows that short-term efforts at acclimatization show little benefit; it is longer term, gradual ascents that display the most benefit. Quick climbs enroute to Mt. Whitney or staying one or two nights at Whitney Portal do not produce the same benefit as staying a altitude for a week or longer at altitude.
Acclimatization takes time, anecdotal testimonies to the contrary. When I lived in the SF Bay Area, it was our typical weekend plan to drive over to the east side on Friday night, get up early on Saturday morning, hike to an 11,000 or 12,000 base camp, bag the peak on Sunday morning, hike out to the trailhead Sunday afternoon, and drive back home late Sunday night. Sound familiar to anyone?
We knew full well the price we might pay for failing to acclimate properly, but we took our lumps without whining too much. LOL.
Hopefully, this information will answer questions regarding acclimatization.
http://wwwnc.cdc.gov/travel/yellowbook/2014/chapter-2-the-pre-travel-consultation/altitude-illnesshttp://www.usariem.army.mil/assets/docs/publications/articles/2004/altitudeacclimatizationguide.pdfhttp://hprc-online.org/environment/altitude/short-duration-altitude-acclimatizationhttp://www.bsa344.com/Guide%20to%20High%20Altitude%20Acclimatization.pdf