Thanks, that helps. Yes, we'd be doing Grand Canyon one-way R2R, not round-trip R2R2R.

It sounds like you've done some very challenging hikes and runs.

I'm surprised you found R2R2R to be easier than Mt. Whitney. By the numbers, R2R2R looks much harder: 42 miles and 10500 feet of climbing, vs "only" 22 miles and 6100 feet for Whitney. Plus R2R2R puts the hardest part last, when you're already most tired. What do you think made R2R2R feel easier than Whitney? The lower altitude? Better trail surface?