pcieluch, you will find many of the people doing those off-trail trips are going solo. I've done a few myself. If you plan it out, it can be fun and rewarding.
The one thing I always take along, though, is a satellite tracking unit. I started with a SPOT, but moved on with an InReach. For me, it is the insurance that, in the rare chance that I get incapacitated, people will be able to find me. I have family at home that wants the reassurance that I'll be coming back. Mine has certainly been the key to unlocking some really good trips.