Diamox has worked for me for general acclimation heading from sea level to 10,000 ft range with little or no time to adjust. I usually start to get a headache and shortness of breath around 9,500 ft or so, but with diamox I feel much better than usual, but still not 100% by any means. Not sure if that qualifies as "general acclimation" but seems like what you're talking about.
I was concerned about the side effects, but never had any issues with the 125 mg 2x/day dosage. I start the day before and taper off within a few days on longer trips. I've tried Ginko Biloba a few times, but it didn't seem to help much. That's my $0.02, keep the change. Your mileage may vary (YMMV).
