late looking at his thread

One man acclimatises quickly, another slowly…The whole process appears to be analogous to sea-sickness about which predictions are impossible.
Eric Shipton, Upon That Mountain page 376

yes, exertion worsens risk of AMS.

will not rehash all the details, but it sounds like some had AMS,
some other, some both

Diamox does not fix everything. Far, far from it.