For Inyo, with 2WD you'll start a little lower than we did and that will make it a slightly longer hike. It's really hard to tell how much snow you'll run into and at what elevation. Most forecasters are predicting a wet winter for the southern part of California (the farmers are smiling at those predictions). You'll just have to wait and see on Inyo regarding how far up you'll be able to get without running into snow/ice.

Here are good directions to Inyo's starting point:

http://www.climber.org/DrivingDirections/InyoNelson.html