Diamox
But the best way to prevent altitude sickness is to go to elevation, 10,000 or more feet as many times as you can before Whitney.
If you're from SoCal, that means Baldy, San Jacinto and San Gorgornio. There are plenty of threads on this site, just do a search for diamox, acclimate, etc.
Besides, diamox can actually make you feel a bit strange, depending on the person.

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