Charged up, yes; but exhausted, very yes!
U.S. 395 heading either direction is a long, dark, mostly straight-for-miles it-all-looks-alike hypnotic road at night, esp. when you're exhausted. Like others above, I don't know how I ever made it to where I was staying (in the Palmdale area) from Lone Pine when driving there the same night as my hike day. I would seriously consider staying in Lone Pine, clean up, sleep, relax, eat, etc. and then head home the following morning refreshed and with the sunlight on the road (395 is a very beautiful drive along the mountains, which beauty is wasted by driving at night when you can't see it).
CaT