Ken, as you and I and others have discussed here,side effects often limit the dose. For me personally anything over 125 twice daily causes significant and bothersome paresthesias (tingling) in the hands,feet, and face to the point of interfering with sleep. The one time I took the sustained release 500 I vowed never to do it again . Others of course will vary, but the 1000/day seems unimaginable
Exactly my experience.
