The only time, I have had severe hypoxia in the Sierra was when I had been on diamox. I started dosing a few days before the trip, went from Reno to Whitney Pass, got caught in a weird July snowstorm, pushed hard to make it over the Pass (skipped going to the top because of the weather and was cold), on the way down I realized I was hypoxic and was having to stop going downhill--breathing too hard. Camped low at Hitchcock Lake. The next day, I was at Tyndall Creek, I remember walking really slow on the flats, the third day went over Forester Pass, that took awhile, climbed down to 10,000, next morning I had a bad case of pulmonary edema. My dad had to walk me out through Cedar Grove, ruined the trip. Now wondering if I had a reaction to Diamox.