Now I just take the one 62.5 mg dose at night before sleeping at altitude, and I no longer take any at all in the days prior to reaching altitude. I take it specifically to address periodic breathing (Cheyne Stokes), the issue to which Ken alludes, since I experienced that phenomenon once on White Mountain, and prefer to avoid it in the future. So far, so good. Even at 62.5 mg/day, I still get some hand tingling....